Upset picks are in italics.
Tuesday
New Mexico State at FIU - Golden Panthers by 14.5
Louisiana at Texas State - Bobcats by 5
Louisiana Tech at Sam Houston - Bearkats by 17
Wednesday
Jacksonville State at Liberty - Flames by 1.5
Kennesaw State at Western Kentucky - Hilltoppers by 33.5
Thursday
Tulane at Charlotte - Green Wave by 11
Houston at NY Jets - Texans by 4.5
Friday
Georgia State at UConn - Huskies by 13.5
South Florida at FAU - Owls by 1.5
San Diego State at (15) Boise State - Broncos by 28.5
Saturday
(4) Ohio State at (3) Penn State - Buckeyes by 1.5
Duke at (5) Miami - Hurricanes by 19
(19) Ole Miss at Arkansas - Rebels by 4
Air Force at (21) Army - Black Knights by 34.5
Minnesota at (24) Illinois - Illini by 3
Northwestern at Purdue - Wildcats by 2.5
Stanford at NC State - Wolfpack by 5.5
Virginia Tech at Syracuse - Hokies by 7.5
Buffalo at Akron - Zips by 0.5
Toledo at Eastern Michigan - Rockets by 4
Memphis at UTSA - Tigers by 7.5
Vanderbilt at Auburn - Commodores by 1
Maine at Oklahoma - Sooners by 24.5
Old Dominion at App State - Monarchs by 6.5
Tulsa at UAB - Blazers by 7
(1) Oregon at Michigan - Ducks by 11
Florida vs. (2) Georgia - Bulldogs by 9.5
Texas Tech at (11) Iowa State - Cyclones by 17.5
(13) Indiana at Michigan State - Hoosiers by 10
(17) Kansas State at Houston - Wildcats by 11.5
UCLA at Nebraska - Cornhuskers by 12
North Carolina at Florida State - Tar Heels by 3
Arizona at UCF - Knights by 11.5
Middle Tennessee at UTEP - Miners by 7
UL Monroe at Marshall - Thundering Herd by 11
Wyoming at New Mexico - Lobos by 4.5
Coastal Carolina at Troy - Chanticleers by 2.5
Navy at Rice - Midshipmen by 12
UMass at Mississippi State - Bulldogs by 12.5
Arizona State at Oklahoma State - Cowboys by 2.5
Hawaii at Fresno State - Bulldogs by 7
(10) Texas A&M at South Carolina - Gamecocks by 3
Louisville at (11) Clemson - Tigers by 7
Wisconsin at Iowa - Hawkeyes by 7
USC at Washington - Trojans by 2
Georgia Southern at South Alabama - Jaguars by 4.5
Kentucky at (7) Tennessee - Volunteers by 16.5
(18) Pittsburgh at (20) SMU - Mustangs by 7
TCU at Baylor - Bears by 7.5
Colorado State at Nevada - Wolf Pack by 5.5
Sunday
Dallas at Atlanta - Falcons by 5
Miami at Buffalo - Bills by 18
Las Vegas at Cincinnati - Bengals by 4
LA Chargers at Cleveland - Chargers by 12.5
New England at Tennessee - Titans by 4.5
Washington at NY Giants - Commanders by 10.5
New Orleans at Carolina - Saints by 12.5
Denver at Baltimore - Broncos by 1
Chicago at Arizona - Bears by 3
Jacksonville at Philadelphia - Eagles by 11.5
Detroit at Green Bay - Lions by 6
LA Rams at Seattle - Rams by 0.5
Indianapolis at Minnesota - Vikings by 9
Monday
Tampa Bay at Kansas City - Chiefs by 1
Results
NCAA: 45-12 (.789) 434-143 overall (.752)
Upsets: 2-2 (.500) 33-46 overall (.418)
NFL: 12-4 (.750) 68-55 overall (.553)
Upsets: 3-1 (.750) 14-27 overall (.341)