Upset picks are in italics.
Thursday
Dallas at Philadelphia - Eagles by 16
Friday
James Madison at Louisville - Cardinals by 13
Western Illinois at Northwestern - Wildcats by 19.5
Northern Illinois at Maryland - Terrapins by 21.5
Eastern Washington at Boise State - Broncos by 19.5
Kansas City vs. LA Chargers - Chiefs by 5
Saturday
FIU at (2) Penn State - Nittany Lions by 27.5
San Jose State at (7) Texas - Longhorns by 43.5
(11) Illinois at Duke - Blue Devils by 3
East Texas A&M at (14) Florida State - Seminoles by 31
Iowa at (16) Iowa State - Cyclones by 12.5
Baylor at (17) SMU - Mustangs by 19.5
Kennesaw State at (23) Indiana - Hoosiers by 27.5
Kent State at (24) Texas Tech - Red Raiders by 32.5
Northwestern State at Minnesota - Gophers by 30
Virginia at NC State - Cavaliers by 0.5
Central Michigan at Pittsburgh - Panthers by 14
UConn at Syracuse - Orange by 6.5
Liberty at Jacksonville State - Gamecocks by 15
Utah State at (19) Texas A&M - Texas A&M Aggies by 29
Western Carolina at Wake Forest - Demon Deacons by 7
Howard at Temple - Owls by 26.5
Idaho State at New Mexico - Lobos by 17
Grambling at (1) Ohio State - Buckeyes by 44
Austin Peay at (4) Georgia - Bulldogs by 43
Oklahoma State at (6) Oregon - Ducks by 23
Troy at (8) Clemson - Tigers by 19.5
(20) Ole Miss at Kentucky - Rebels by 5
East Tennessee State at (22) Tennessee - Volunteers by 42
Kansas vs. Missouri - Tigers by 6.5
Miami (OH) at Rutgers - Scarlet Knights by 12.5
Fresno State at Oregon State - Bulldogs by 15.5
Gardner-Webb at Georgia Tech - Yellowjackets by 38.5
Bowling Green at Cincinnati - Bearcats by 15
Delaware at Colorado - Buffaloes by 23.5
Lindenwood at App State - Mountaineers by 26.5
Texas State at UTSA - Roadrunners by 3.5
UAB at Navy - Midshipmen by 25.5
North Texas at Western Michigan - Broncos by 1.5
Saint Francis at Buffalo - Bulls by 25.5
Bryant at UMass - Bulldogs by 7
Middle Tennessee at Wisconsin - Badgers by 48
West Virginia at Ohio - Bobcats by 1.5
Northern Iowa at Wyoming - Cowboys by 23
South Florida at (13) Florida - Gators by 3.5
Arkansas State at Arkansas - Razorbacks by 20
Sacramento State at Nevada - Wolf Pack by 19.5
Jackson State at Southern Miss - Tigers by 1
Cal Poly at (25) Utah - Utes by 43
Texas Southern at California - Bears by 34
Missouri State at Marshall - Thundering Herd by 22.5
NC Central at Old Dominion - Monarchs by 29
Campbell at East Carolina - Pirates by 22
Florida A&M at Florida Atlantic - Owls by 8
Bethune-Cookman at (5) Miami - Hurricanes by 39
South Carolina State at (10) South Carolina - Gamecocks by 42
North Carolina at Charlotte - 49ers by 3
Army at Kansas State - Wildcats by 19
Houston at Rice - Owls by 12.5
North Carolina A&T at UCF - Knights by 23.5
Western Kentucky at Toledo - Rockets by 9
Northern Colorado at Colorado State - Rams by 19
Memphis at Georgia State - Tigers by 1.5
Tulane at South Alabama - Green Wave by 3.5
Long Island at Eastern Michigan - Eagles by 13.5
Louisiana Tech at (3) LSU - Tigers by 28.5
(12) Arizona State at Mississippi State - Bulldogs by 6.5
(15) Michigan at (18) Oklahoma - Sooners by 8
Ball State at Auburn - Tigers by 43.5
Vanderbilt at Virginia Tech - Hokies by 10
Akron at Nebraska - Cornhuskers by 33.5
Georgia Southern at USC - Trojans by 25.5
Boston College at Michigan State - Spartans by 6
Southern Illinois at Purdue - Boilermakers by 22.5
Charleston Southern at Coastal Carolina - Chanticleers by 9.5
UL Monroe at (21) Alabama - Crimson Tide by 14
UCLA at UNLV - Rebels by 27
McNeese at Louisiana - Ragin Cajuns by 15
Tulsa at New Mexico State - Aggies by 4
UT Martin at UTEP - Miners by 8.5
Weber State at Arizona - Wildcats by 25.5
San Diego State at Washington State - Cougars by 1.5
Stanford at BYU - Cougars by 20
UC Davis at Washington - Huskies by 27.5
Sam Houston at Hawaii - Warriors by 5
Sunday
Arizona at New Orleans - Cardinals by 10
Tampa Bay at Atlanta - Buccaneers by 9.5
Cincinnati at Cleveland - Bengals by 20.5
Miami at Indianapolis - Dolphins by 4
Las Vegas at New England - Raiders by 1
Pittsburgh at NY Jets - Steelers by 6
NY Giants at Washington - Commanders by 16
Carolina at Jacksonville - Jaguars by 11
Tennessee at Denver - Broncos by 13.5
San Francisco at Seattle - 49ers by 7.5
Detroit at Green Bay - Lions by 6.5
Houston at LA Rams - Rams by 3.5
Baltimore at Buffalo - Ravens by 2.5
Monday
Minnesota at Chicago - Vikings by 11.5
Results
NCAA: 78-13 (.857) 83-13 overall (.865)
Upsets: 3-5 (.375) 4-5 overall (.444)
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