Upset picks are in italics.
Tuesday
Akron at Kent State - Zips by 5
Western Michigan at Central Michigan - Broncos by 5
Northern Illinois at Miami (OH) - Redhawks by 2
Wednesday
Buffalo at Eastern Michigan - Eagles by 2.5
Ohio at Toledo - Rockets by 5
Thursday
NC State at Georgia Tech - Yellowjackets by 13
Pittsburgh at Cleveland - Steelers by 15.5
Friday
Temple at UTSA - Roadrunners by 13
Purdue at Michigan State - Spartans by 12.5
UNLV at San Jose State - Rebels by 9
Saturday
(5) Indiana at (2) Ohio State - Buckeyes by 8.5
Wake Forest at (8) Miami - Hurricanes by 23
(9) Ole Miss at Florida - Rebels by 8
(13) SMU at Virginia - Mustangs by 9
(25) Illinois at Rutgers - Scarlet Knights by 2
Iowa at Maryland - Hawkeyes by 8
UConn at Syracuse - Orange by 10.5
North Carolina at Boston College - Eagles by 2.5
Sam Houston at Jacksonville State - Gamecocks by 3
UMass at (10) Georgia - Bulldogs by 36
UTEP at (11) Tennessee - Volunteers by 34
Western Kentucky at Liberty - Hilltoppers by 3.5
Charleston Southern at Florida State - Seminoles by 15.5
Bowling Green at Ball State - Falcons by 8.5
Rice at UAB - Owls by 1
New Mexico State at Middle Tennessee - Blue Raiders by 5
James Madison at App State - Dukes by 9
Arizona at TCU - Horned Frogs by 12
FIU at Kennesaw State - Panthers by 6.5
UL Monroe at Arkansas State - Red Wolves by 0.5
South Alabama at Southern Miss - Jaguars by 15.5
Charlotte at FAU - Owls by 2.5
Kentucky at (3) Texas - Longhorns by 19.5
(4) Penn State at Minnesota - Nittany Lions by 5.5
(14) BYU at (21) Arizona State - Sun Devils by 0.5
(16) Colorado at Kansas - Buffaloes by 0.5
Citadel at (17) Clemson - Tigers by 34
Northwestern at Michigan - Wolverines by 8.5
Wisconsin at Nebraska - Cornhuskers by 4
Stanford at California - Bears by 13.5
Texas Tech at Oklahoma State - Red Raiders by 0.5
UCF at West Virginia - Mountaineers by 1
San Diego State at Utah State - Aggies by 4
Georgia Southern at Coastal Carolina - Chanticleers by 0.5
East Carolina at North Texas - Mean Green by 4
Tulsa at South Florida - Bulls by 18.5
Pittsburgh at Louisville - Cardinals by 9
Wofford at (18) South Carolina - Gamecocks by 37.5
Louisiana Tech at Arkansas - Razorbacks by 18.5
(23) Missouri at Mississippi State - Tigers by 7
Troy at Louisiana - Ragin Cajuns by 14.5
(19) Army vs. (6) Notre Dame - Irish by 8.5
(12) Boise State at Wyoming - Broncos by 23.5
Washington State at Oregon State - Cougars by 7.5
Baylor at Houston - Bears by 6
Georgia State at Texas State - Bobcats by 20
(7) Alabama at Oklahoma - Crimson Tide by 11.5
(15) Texas A&M at Auburn - Aggies by 3.5
(22) Iowa State at Utah - Cyclones by 6
Marshall at Old Dominion - Monarchs by 3
Vanderbilt at LSU - Tigers by 7
Cincinnati at Kansas State - Wildcats by 7.5
Virginia Tech at Duke - Hokies by 4
USC at UCLA - Trojans by 5
Air Force at Nevada - Wolf Pack by 8.5
Colorado State at Fresno State - Bulldogs by 3.5
Sunday
Minnesota at Chicago - Vikings by 8
Detroit at Indianapolis - Lions by 11.5
New England at Miami - Dolphins by 3.5
Tampa Bay at NY Giants - Buccaneers by 10.5
Dallas at Washington - Commanders by 11.5
Kansas City at Carolina - Chiefs by 19
Tennessee at Houston - Texans by 9.5
Denver at Las Vegas - Broncos by 13.5
Arizona at Seattle - Cardinals by 3.5
San Francisco at Green Bay - Packers by 3
Philadelphia at LA Rams - Eagles by 5.5
Monday
Baltimore at LA Chargers - Chargers by 0.5
Results
NCAA: 38-17 (.691) 539-192 overall (.737)
Upsets: 2-3 (.400) 42-56 overall (.429)
NFL: 12-2 (.857) 100-66 overall (.602)
Upsets: 2-1 (.667) 17-32 overall (.347)